Document Type
Article
Publication Date
11-9-2009
Journal or Book Title
Journal of Agricultural and Food Chemistry
Volume
58
Issue
1
First Page
141
Last Page
147
DOI
10.1021/jf902284u
Abstract
-OH-flavonoids disappeared more rapidly from human fecal incuba- tions and were less absorbable by humans than flavonoids without 5-OH moieties. Anaerobic fecal disappearance rates over 24 h were determined for 15 flavonoids in samples from 20 men and 13 women. In these anaerobic fecal mixtures, flavonoids with 5,7,40-OH groups, genistein, apigenin, naringenin, luteolin, kaempferol, and quercetin (disappearance rate, k = 0.46 ( 0.10 h-1), and methoxylated flavonoids, hesperetin and glycitein (k = 0.24 ( 0.21 h-1), disappeared rapidly compared with flavonoids lacking 5-OH (e.g., daidzein, k = 0.07 ( 0.03 h-1). Apparent absorption of flavonoids that disappeared rapidly from in vitro fecal incubations, genistein, naringenin, quercetin, and hesperetin, was compared with that of daidzein, a slowly disappearing flavonoid, in 5 men and 5 women. Subjects ingested 104 μmol of genistein and 62 μmol of daidzein (soy milk), 1549 μmol of naringenin and 26 μmol of hesperetin (grapefruit juice), and 381 μmol of quercetin (onions) in three test meals, each separated by 1 week. Blood and urine samples were collected over 24 h after each test meal. Plasma flavonoid concentrations ranged from 0.01 to 1 μM. The apparent absorption, expressed as percentage of ingested dose excreted in urine, was significantly less for naringenin (3.2 ( 1.7%), genistein (7.2 ( 4.6%), hesperetin (7.3 ( 3.2%), and quercetin (5.6 ( 3.7%) compared with daidzein (43.4 ( 15.5%, p = 0.02). These data affirmed the hypothesis that the 5,7,40-OH of flavonoids limited apparent absorption of these compounds in humans.
Copyright Owner
American Chemical Society
Copyright Date
2009
Language
en
File Format
application/pdf
Recommended Citation
Simons, Andrean L.; Renouf, Mathieu; Murphy, Patricia A.; and Hendrich, Suzanne, "Greater Apparent Absorption of Flavonoids Is Associated with Lesser Human Fecal Flavonoid Disappearance Rates" (2009). Food Science and Human Nutrition Publications. 83.
https://lib.dr.iastate.edu/fshn_ag_pubs/83
Included in
Food Science Commons, Human and Clinical Nutrition Commons, Molecular, Genetic, and Biochemical Nutrition Commons
Comments
Reprinted with permission from Journal of Agricultural and Food Chemistry,58(1)2009: 141-147. doi: 10.1021/jf902284u. Copyright 2009 American Chemical Society.