Title
Efficacy of a Mycotoxin Binder against Dietary Fumonisin, Deoxynivalenol, and Zearalenone in Rats
Document Type
Article
Publication Date
6-8-2011
Journal or Book Title
Journal of Agricultural and Food Chemistry
Volume
59
Issue
13
First Page
7527
Last Page
7533
DOI
10.1021/jf202042z
Abstract
It was hypothesized that a mycotoxin binder, Grainsure E, would inhibit adverse effects of a mixture of fumonisin B1, deoxynivalenol, and zearalenone in rats. For 14 and 28 days, 8–10 Sprague–Dawley rats were fed control diet, Grainsure E (0.5%), toxins (7 μg fumonisin B1/g, 8 μg of deoxynivalenol/g and 0.2 μg of zearalenone/g), toxins (12 μg of fumonisin B1/g, 9 μg of deoxynivalenol/g, and 0.2 μg of zearalenone/g + Grainsure E), or pair-fed to control for food intake of toxin-fed rats. After 28 days, decreased body weight gain was prevented by Grainsure E in toxin-fed female rats, indicating partial protection against deoxynivalenol and fumonisin B1. Two effects of fumonisin B1 were partly prevented by Grainsure E in toxin-fed rats, increased plasma alanine transaminase (ALT) and urinary sphinganine/sphingosine, but sphinganine/sphingosine increase was not prevented in females at the latter time point. Grainsure E prevented some effects of fumonisin B1 and deoxynivalenol in rats.
Rights
One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions.).
Copyright Owner
American Chemical Society
Copyright Date
2011
Language
en
File Format
application/pdf
Recommended Citation
Zhang, Qiang; Truong, My; Meynen, Koen; Murphy, Patricia A.; and Hendrich, Suzanne, "Efficacy of a Mycotoxin Binder against Dietary Fumonisin, Deoxynivalenol, and Zearalenone in Rats" (2011). Food Science and Human Nutrition Publications. 86.
https://lib.dr.iastate.edu/fshn_ag_pubs/86
Included in
Food Science Commons, Human and Clinical Nutrition Commons, Other Animal Sciences Commons
Comments
Reprinted with permission from Journal of Agricultural and Food Chemistry, 59(13)2011:7527-7533. doi: 10.1021/jf202042z. Copyright 2011 American Chemical Society.