Title
Excretion of 14C-Fumonisin B1, 14C-Hydrolyzed Fumonisin B1, and 14C-Fumonisin B1-Fructose in Rats
Document Type
Article
Publication Date
9-14-1999
Journal or Book Title
Journal of Agricultural and Food Chemistry
Volume
47
Issue
10
First Page
4291
Last Page
4296
DOI
10.1021/jf981340v
Abstract
14C-Fumonisin B1 (FB1) was produced by Fusarium proliferatum M-5991 in modified Myro liquid medium and purified to >95% purity with a specific activity of 1.7 mCi/mmol. Nine male and nine female F344/N rats were each dosed by gavage with 0.69 μmol of 14C-FB1, 14C-hydrolyzed FB1, or 14C-FB1-fructose/kg body weight. Urinary excretion of 14C-FB1 and 14C-FB1-fructose was 0.5% and 4.4% of the total dose, respectively, and was similar between male and female rats. Urinary excretion of 14C-hydrolyzed HFB1 was significantly greater (P > 0.05) in female rats as compared with male rats (17.3% vs 12.8% of the total dose, respectively). There were no significant (P > 0.05) differences in biliary excretion of the three fumonisin compounds with a mean of 1.4% of the dose excreted at 4 h after dosing. Lesser amounts continued to be excreted up to 9.25 h after dosing. Although biliary excretion of the14C-FB1, 14C-hydrolyzed FB1, and 14C-FB1-fructose was similar, increased urinary excretion of the 14C-hydrolyzed FB1 as compared to 14C-FB1 and 14C-FB1-fructose indicated a greater absorption of the hydrolyzed form.
Rights
One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions).
Copyright Owner
American Chemical Society
Copyright Date
1999
Language
en
File Format
application/pdf
Recommended Citation
Dantzer, William R.; Hopper, Joan; Mullin, Kathleen; Hendrich, Suzanne; and Murphy, Patricia A., "Excretion of 14C-Fumonisin B1, 14C-Hydrolyzed Fumonisin B1, and 14C-Fumonisin B1-Fructose in Rats" (1999). Food Science and Human Nutrition Publications. 91.
https://lib.dr.iastate.edu/fshn_ag_pubs/91
Included in
Comparative and Laboratory Animal Medicine Commons, Food Science Commons, Human and Clinical Nutrition Commons, Other Veterinary Medicine Commons
Comments
Reprinted with permission from Journal of Agricultural and Food Chemistry, 47(10):4291-4296. doi: 10.1021/jf981340v. Copyright 1999 American Chemical Society.