Campus Units
Food Science and Human Nutrition
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
1-2010
Journal or Book Title
Biofactors
Volume
36
Issue
1
First Page
19
Last Page
24
DOI
10.1002/biof.71
Abstract
Homocysteine is a metabolic intermediate in methyl group metabolism that is dependent on a number of nutritional B-vitamin cofactors. An emerging aspect of homocysteine metabolism is its relation to health and disease. Perturbations of homocysteine metabolism, particularly intracellular and subsequently circulating accumulation of homocysteine (i.e., hyperhomocysteinemia), are associated with vascular disease risk, as well as other pathologies. However, intervention with B-vitamin supplementation has been shown to successfully restore normal homocysteine concentrations, but without concomitant reductions in disease risk. Thus, the mechanistic relation between homocysteine balance and disease states, as well as the value of homocysteine management, remains an area of intense investigation.
Copyright Owner
Wiley
Copyright Date
2010
Language
en
File Format
application/pdf
Recommended Citation
Williams, Kelly T. and Schalinske, Kevin, "Homocysteine metabolism and its relation to health and disease." (2010). Food Science and Human Nutrition Publications. 10.
https://lib.dr.iastate.edu/fshn_hs_pubs/10
Included in
Food Chemistry Commons, Human and Clinical Nutrition Commons, Other Food Science Commons
Comments
This is the peer reviewed version of the following article from Biofactors, 2010 36(1); 19-24, which has been published in final form at Doi: 10.1002/biof.71. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.