Campus Units
Genetics, Development and Cell Biology, Plant Pathology and Microbiology
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
4-10-2017
Journal or Book Title
Developmental Cell
Volume
41
Issue
1
First Page
33
Last Page
46.e7
DOI
10.1016/j.devcel.2017.03.013
Abstract
Plants encounter a variety of stresses and must fine-tune their growth and stress-response programs to best suit their environment. BES1 functions as a master regulator in the brassinosteroid (BR) pathway that promotes plant growth. Here, we show that BES1 interacts with the ubiquitin receptor protein DSK2 and is targeted to the autophagy pathway during stress via the interaction of DSK2 with ATG8, a ubiquitin-like protein directing autophagosome formation and cargo recruitment. Additionally, DSK2 is phosphorylated by the GSK3-like kinase BIN2, a negative regulator in the BR pathway. BIN2 phosphorylation of DSK2 flanking its ATG8 interacting motifs (AIMs) promotes DSK2-ATG8 interaction, thereby targeting BES1 for degradation. Accordingly, loss-of-function dsk2 mutants accumulate BES1, have altered global gene expression profiles, and have compromised stress responses. Our results thus reveal that plants coordinate growth and stress responses by integrating BR and autophagy pathways and identify the molecular basis of this crosstalk.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Copyright Owner
Elsevier Inc.
Copyright Date
2017
Language
en
File Format
application/pdf
Recommended Citation
Nolan, Trevor M.; Brennan, Benjamin; Yang, Mengran; Chen, Jiani; Zhang, Mingcai; Li, Zhaohu; Wang, Xuelu; Bassham, Diane C.; Walley, Justin; and Yin, Yanhai, "Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival" (2017). Genetics, Development and Cell Biology Publications. 210.
https://lib.dr.iastate.edu/gdcb_las_pubs/210
Included in
Cell Biology Commons, Developmental Biology Commons, Genetics Commons, Plant Biology Commons
Comments
This is a manuscript of an article published as Nolan, Trevor M., Benjamin Brennan, Mengran Yang, Jiani Chen, Mingcai Zhang, Zhaohu Li, Xuelu Wang, Diane C. Bassham, Justin Walley, and Yanhai Yin. "Selective autophagy of BES1 mediated by DSK2 balances plant growth and survival." Developmental cell 41, no. 1 (2017): 33-46.e7. doi: 10.1016/j.devcel.2017.03.013. Posted with permission.