Campus Units
Animal Science, Food Science and Human Nutrition, Genetics, Development and Cell Biology, Kinesiology, Microbiology, Neuroscience
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
2009
Journal or Book Title
Phytomedicine
Volume
16
Issue
6-7
First Page
669
Last Page
678
DOI
10.1016/j.phymed.2009.02.010
Abstract
Healing of open skin wounds begins with an inflammatory response. Restraint stress has been well documented to delay wound closure, partially via glucocorticoid (GC)-mediated immunosuppression of inflammation. Echinacea, a popular herbal immunomodulator, is purported to be beneficial for wound healing. To test the hypothesis, an alcohol extract of E. pallida was administrated orally to mice for 3 days prior to, and 4 days post wounding with a dermal biopsy on the dorsum. Concominantly, mice were exposed to 3 cycles of daily restraint stress prior to, and 4 cycles post wounding. Echinacea accelerated wound closure in the stressed mice, but had no apparent wound healing effect for the non-stressed mice when compared to their respective controls. To test if the positive healing effect is through modulation of GC release, plasma corticosterone concentrations were measured in unwounded mice treated with restraint stress and the herbal extract for 4 days. Plasma GC in restraint stressed mice gavaged with Echinacea was not different from mice treated with restraint only, but was increased compared to the vehicle control. This data suggests that the improved wound healing effect of Echinacea in stressed mice is not mediated through modulation of GC signaling.
Rights
© 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Copyright Owner
Elsevier GmbH
Copyright Date
2009
Language
en
File Format
application/pdf
Recommended Citation
Zhai, Zili; Haney, Devon M.; Wu, Lankun; Solco, Avery K.; Murphy, Patricia A.; Wurtele, Eve S.; Kohut, Marian L.; and Cunnick, Joan E., "Alcohol extract of Echinacea pallida reverses stress-delayed wound healing in mice" (2009). Genetics, Development and Cell Biology Publications. 75.
https://lib.dr.iastate.edu/gdcb_las_pubs/75
Included in
Cell and Developmental Biology Commons, Kinesiology Commons, Microbiology Commons, Neuroscience and Neurobiology Commons, Zoology Commons
Comments
This is a manuscript of an article from Phytomedicine 16 (2009): 669, doi: 10.1016/j.phymed.2009.02.010. Posted with permission.