At Tinos Island, Greece, the physicochemical evolution of the hydrothermal system and the associated stages of metallic mineralization that are developed in the vicinity of the Tinos granodiorite-leucogranite has been studied, based on fluid inclusion studies and chemical reactions modeling. Early tungsten mineraliozation was related to the metasomatic stage of contact metamorphism and precipitated at ~ 350oC, from moderate saline (10.4 to 14.8 wt% NaCl eq.), CO2- effervescing fluids, that contained variable amounts of CaCl2 and MgCl2. Panormos Bay Au-Ag-Te mineralization, located 16 km away from the intrusive site, was deposited from cooler 200° to 300oC, and low to moderate saline (0.2 to 13.2 wt% NaCl eq.) mineralizing fluids. Au-Ag mineralization at Apigania Bay, which represents a late evolutionary phase, was deposited from even cooler (125o to 235oC) and dilute (0.2 to 6.8 wt % NaCl eq.) fluids. In all, the mineralization stage precipitation was controlled by two principal factors: the exsolution of gaseous phase and an increase in pH from 3.3 to 7.6.