Satellite-derived potential evapotranspiration (PET) estimates computed from Moderate Resolution Imaging Spectroradiometer (MODIS) observations and the Priestley-Taylor formula (M-PET) are evaluated as input to the Hydrology Laboratory Research Distributed Hydrologic Model (HL-RDHM). The HL-RDHM is run at a 4-km spatial and 6-h temporal resolution for 13 watersheds in the upper Mississippi and Red River basins for 2003-10. Simulated discharge using inputs of daily M-PET is evaluated for all watersheds, and simulated evapotranspiration (ET) is evaluated at two watersheds using nearby latent heat flux observations. M-PET-derived model simulations are compared to output using the long-term average PET values (default-PET) provided as part of theHL-RDHMapplication. In addition, uncalibrated and calibrated simulations are evaluated for both PET data sources. Calibrating select model parameters is found to substantially improve simulated discharge for both datasets. Overall average percent bias (PBias) and Nash-Sutcliffe efficiency (NSE) values for simulated discharge are better from the default-PET than the M-PET for the calibrated models during the verification period, indicating that the time-varying M-PET input did not improve the discharge simulation in theHL-RDHM. M-PET tends to produce higher NSE values than the default-PET for the Wisconsin and Minnesota basins, but lower NSE values for the Iowa basins. M-PET-simulated ET matches the range and variability of observed ET better than the default-PET at two sites studied and may provide potential model improvements in that regard.