Use of a Novel Adjuvant in a Leptospira borgpetersenii Hardjo Vaccine to Induce a Cell-Mediated Immune Response
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The Department of Genetics, Development, and Cell Biology seeks to teach subcellular and cellular processes, genome dynamics, cell structure and function, and molecular mechanisms of development, in so doing offering a Major in Biology and a Major in Genetics.
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The Department of Genetics, Development, and Cell Biology was founded in 2005.
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- College of Agriculture and Life Sciences (parent college)
- College of Liberal Arts and Sciences (parent college)
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The Honors project is potentially the most valuable component of an Honors education. Typically Honors students choose to do their projects in their area of study, but some will pick a topic of interest unrelated to their major.
The Honors Program requires that the project be presented at a poster presentation event. Poster presentations are held each semester. Most students present during their senior year, but may do so earlier if their honors project has been completed.
This site presents project descriptions and selected posters for Honors projects completed since the Fall 2015 semester.
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Abstract
Infection of cattle with Leptospira borgpetersenii serovar Hardjo can have negative impacts on the cattle industry and pose the risk of transmission to other mammals, including humans. Current commercial vaccines used to protect against Leptospira serovar Hardjo are ineffective at providing long-term immunity, and a more cell-mediated immune response is thought to be necessary for lasting protection. IgG1 and IgG2 levels can be indicative of what type of a T cell response predominates; in a cell-mediated type 1 (Th1) immune response, interferon-ү (IFN-ү) secreted from helper T cells will stimulate B cells to class-switch to manufacture and secrete IgG2. In a humoral type 2 (Th2) immune response, helper T cells secrete interleukin-4 (IL-4) that stimulates B cells to class-switch to manufacture and secrete antibodies of the IgG1 isotype. In this study, a novel vaccine formulated with an oil-based adjuvant was shown to induce a stronger and more balanced cell-mediated response in comparison with current commercial serovar Hardjo vaccines. This was demonstrated by analyzing antibody levels in response to vaccination and challenge with Leptospira serovar Hardjo.