Date

1-4-2017 12:00 AM

Major

Nutritional Sciences

Department

Food Science and Human Nutrition

College

College of Human Sciences

Project Advisor

Wendy White

Project Advisor's Department

Human Sciences

Description

Background: Prokineticin (PROK2) is a secreted protein expressed in the small intestine. It has also been associated with protecting brain cells by stimulates neurons to produce more mitochondria. Methods: Exploratory analysis was conducted in PLINK to extract SNP’s in Chromosome 3 (location of PROK2) that are related to bioenergetics and metabolism from the ADNI data, which contains longitudinal data including demographic, cognitive, neuroimaging, and biochemical data. Afterwards, the minor allele information was obtained for each of the SNPs. Then, linear mixed modeling in SPSS 23 was done to test associations between these genes associated with PROK2 and Alzheimer’s disease outcomes. Finally, SPM 12 was used to regress brain volume against genotype information to determine how these genetic factors alter brain structure. Results: SPSS 23 results did not show a significant association between subjects that presented the minor allele in the SNPs related to PROK2. SPM12 brain volume regression results showed a significant association between a decrease of grey matter in the brain and an increase in minor allele frequency for rs1512321 (Ke=648,459,459). A significant association was also found between an increased frequency in rs1512321 minor alleles and FDG (marker for tissue uptake of glucose) (Ke=723).

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Apr 1st, 12:00 AM

Genetic influences of PROK2 associated genes affecting Alzheimer’s disease outcomes

Background: Prokineticin (PROK2) is a secreted protein expressed in the small intestine. It has also been associated with protecting brain cells by stimulates neurons to produce more mitochondria. Methods: Exploratory analysis was conducted in PLINK to extract SNP’s in Chromosome 3 (location of PROK2) that are related to bioenergetics and metabolism from the ADNI data, which contains longitudinal data including demographic, cognitive, neuroimaging, and biochemical data. Afterwards, the minor allele information was obtained for each of the SNPs. Then, linear mixed modeling in SPSS 23 was done to test associations between these genes associated with PROK2 and Alzheimer’s disease outcomes. Finally, SPM 12 was used to regress brain volume against genotype information to determine how these genetic factors alter brain structure. Results: SPSS 23 results did not show a significant association between subjects that presented the minor allele in the SNPs related to PROK2. SPM12 brain volume regression results showed a significant association between a decrease of grey matter in the brain and an increase in minor allele frequency for rs1512321 (Ke=648,459,459). A significant association was also found between an increased frequency in rs1512321 minor alleles and FDG (marker for tissue uptake of glucose) (Ke=723).