Date

2018 12:00 AM

Major

Nutritional Science

Department

Food Science and Human Nutrition

College

Agriculture and Life Sciences

Project Advisor

Jelena Kraft

Description

Obesity is one of the greatest health concerns worldwide and has been progressively increasing over the years. The World Health Organization has estimated that 1.9 billion adults were overweight in 2014 and out of the 1.9 billion overweight adults, about 600 million adults were considered obese. This epidemic has generated much scientific interest in many fields, including genetics. The most common human gene studied for obesity has been the Fat Mass and Obesity Associated gene (FTO gene). The FTO gene has had the strongest correlations to excess body mass, fat mass and Body Mass Index (BMI) in clinical studies. While the FTO gene’s function is not entirely understood, scientific studies have shown that people who have certain FTO gene variants, called Single Nucleotide Polymorphism (SNP), specifically the SNP rs 9939609 are more likely to have larger appetites, and as such, are more vulnerable to weight gain and higher BMIs. The purpose of this project is to learn more about the FTO gene variants and evaluate my own FTO gene region. I will be using genetic sequencing techniques to compare it with the FTO gene variants found in the NCBI GenBank.

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Jan 1st, 12:00 AM

Association between the FTO Gene and Obesity

Obesity is one of the greatest health concerns worldwide and has been progressively increasing over the years. The World Health Organization has estimated that 1.9 billion adults were overweight in 2014 and out of the 1.9 billion overweight adults, about 600 million adults were considered obese. This epidemic has generated much scientific interest in many fields, including genetics. The most common human gene studied for obesity has been the Fat Mass and Obesity Associated gene (FTO gene). The FTO gene has had the strongest correlations to excess body mass, fat mass and Body Mass Index (BMI) in clinical studies. While the FTO gene’s function is not entirely understood, scientific studies have shown that people who have certain FTO gene variants, called Single Nucleotide Polymorphism (SNP), specifically the SNP rs 9939609 are more likely to have larger appetites, and as such, are more vulnerable to weight gain and higher BMIs. The purpose of this project is to learn more about the FTO gene variants and evaluate my own FTO gene region. I will be using genetic sequencing techniques to compare it with the FTO gene variants found in the NCBI GenBank.