Date

2019 12:00 AM

Major

Chemical and Biological Engineering

Department

Chemical and Biological Engineering

College

Engineering

Project Advisor

Balaji Narasimhan

Description

Medical treatment for older adults is challenging due to co-existing and interacting chronic conditions, administration of multiple medications, cross-reactivity, and deficits in immune response. Polyanhydride-based nanomedicines could help address these problems by delivering drugs over an extended period of time, customizing their release kinetics, and reducing drug dosage. In this study, we investigated the role of drug chemistry, polymer chemistry, and nanoparticle properties on drug release kinetics. This information can lead to rational design of nanomedicines for older adults. Copolymers were synthesized from 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG), poly 1,6-bis(p-carboxyphenoxy) hexane (CPH), and sebacic acid (SA). Six drugs commonly used in aged adult care were identified for testing: acebutolol, aspirin, hydrochlorothiazide, levothyroxine, metformin, and simvastatin. These drugs, representing varying physicochemical properties, were encapsulated in nanoparticles composed of either 20:80 CPTEG:CPH or 20:80 CPH:SA copolymers. A semi-automated, high-throughput method was used to rapidly synthesize the nanoparticle library. Release kinetics were assayed in neutral buffered conditions at 37°C, crudely simulating body conditions.

File Format

application/pdf

Share

COinS
 
Jan 1st, 12:00 AM

High-throughput Synthesis of Nanomedicines for Aged Adults

Medical treatment for older adults is challenging due to co-existing and interacting chronic conditions, administration of multiple medications, cross-reactivity, and deficits in immune response. Polyanhydride-based nanomedicines could help address these problems by delivering drugs over an extended period of time, customizing their release kinetics, and reducing drug dosage. In this study, we investigated the role of drug chemistry, polymer chemistry, and nanoparticle properties on drug release kinetics. This information can lead to rational design of nanomedicines for older adults. Copolymers were synthesized from 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG), poly 1,6-bis(p-carboxyphenoxy) hexane (CPH), and sebacic acid (SA). Six drugs commonly used in aged adult care were identified for testing: acebutolol, aspirin, hydrochlorothiazide, levothyroxine, metformin, and simvastatin. These drugs, representing varying physicochemical properties, were encapsulated in nanoparticles composed of either 20:80 CPTEG:CPH or 20:80 CPH:SA copolymers. A semi-automated, high-throughput method was used to rapidly synthesize the nanoparticle library. Release kinetics were assayed in neutral buffered conditions at 37°C, crudely simulating body conditions.