Development of transition-metal catalyzed cross-coupling reactions involving amide electrophiles with heterocyclic nucleophiles
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The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).
History
The Department of Chemistry was founded in 1880.
Dates of Existence
1880-present
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- College of Liberal Arts and Sciences (parent college)
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The Honors project is potentially the most valuable component of an Honors education. Typically Honors students choose to do their projects in their area of study, but some will pick a topic of interest unrelated to their major.
The Honors Program requires that the project be presented at a poster presentation event. Poster presentations are held each semester. Most students present during their senior year, but may do so earlier if their honors project has been completed.
This site presents project descriptions and selected posters for Honors projects completed since the Fall 2015 semester.
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Abstract
There are many technological challenges that face society today, one of which is the ability to develop precise control over chemical reactions. Many of the high-value molecules used as pharmaceuticals, agrochemicals, and important materials must be made using synthetic techniques. These industries require efficient and cost-effective methods to synthesize their products. Cross-coupling reactions are one such method that have become heavily used. Although amides are an extremely prevalent and important functional group, there has been little investigation into performing these cross-coupling reactions with amide as coupling partners. Thus, it remains a challenge in the field of organic synthesis. We have demonstrated reactivity for cross-coupling reactions with amide electrophiles and heterocycle nucleophiles in order to generate ketone products containing heterocyclic units. By targeting these medicinally-important heterocyclic compounds, this research will be useful in making important target compounds more accessible while also developing a new class of electrophiles to use in cross-coupling reactions.