Date

2019 12:00 AM

Major

Chemistry

Department

Chemistry

College

Liberal Arts and Sciences

Project Advisor

Levi Stanley

Description

There are many technological challenges that face society today, one of which is the ability to develop precise control over chemical reactions. Many of the high-value molecules used as pharmaceuticals, agrochemicals, and important materials must be made using synthetic techniques. These industries require efficient and cost-effective methods to synthesize their products. Cross-coupling reactions are one such method that have become heavily used. Although amides are an extremely prevalent and important functional group, there has been little investigation into performing these cross-coupling reactions with amide as coupling partners. Thus, it remains a challenge in the field of organic synthesis. We have demonstrated reactivity for cross-coupling reactions with amide electrophiles and heterocycle nucleophiles in order to generate ketone products containing heterocyclic units. By targeting these medicinally-important heterocyclic compounds, this research will be useful in making important target compounds more accessible while also developing a new class of electrophiles to use in cross-coupling reactions.

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Jan 1st, 12:00 AM

Development of transition-metal catalyzed cross-coupling reactions involving amide electrophiles with heterocyclic nucleophiles

There are many technological challenges that face society today, one of which is the ability to develop precise control over chemical reactions. Many of the high-value molecules used as pharmaceuticals, agrochemicals, and important materials must be made using synthetic techniques. These industries require efficient and cost-effective methods to synthesize their products. Cross-coupling reactions are one such method that have become heavily used. Although amides are an extremely prevalent and important functional group, there has been little investigation into performing these cross-coupling reactions with amide as coupling partners. Thus, it remains a challenge in the field of organic synthesis. We have demonstrated reactivity for cross-coupling reactions with amide electrophiles and heterocycle nucleophiles in order to generate ketone products containing heterocyclic units. By targeting these medicinally-important heterocyclic compounds, this research will be useful in making important target compounds more accessible while also developing a new class of electrophiles to use in cross-coupling reactions.