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Iowa State University Veterinarian

Document Type

Article

Abstract

The pathogenesis of canine distemper was well described by Max Appel (1969). Upon infection by inhalation or ingestion, the virus first invades the tonsils and bronchial lymph nodes. During the first week, the virus spreads to the rest of the lymphoid tissues, including the spleen, thymus, and bone marrow, causing a leukopenia and a transient fever.

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