Campus Units

Kinesiology, Chemical and Biological Engineering, Statistics

Document Type

Article

Publication Version

Published Version

Publication Date

5-10-2014

Journal or Book Title

Journal of Bioinformatics and Diabetes

Volume

1

Issue

1

First Page

19

DOI

10.14302/issn.2374-9431.jbd-13-283

Abstract

Continuous-time glucose monitoring (CGM) effectively improves glucose control, as oppose to infrequent glucose measurements (i.e. using Lancet Meters), by providing frequent blood glucose concentration (BGC) to better associate this variation with changes in behavior. Currently, the most widely used CGM devices rely on a sensor that is inserted invasively under the skin. Because of the invasive nature and also the replacement cost of sensors, the primary users of current CGM devices are insulin dependent people (type 1 and some type 2 diabetics). Most non-insulin dependent diabetics use only lancet glucose measurements. The ultimate goal of this research is the development of CGM technology that overcomes these limitations (i.e. invasive sensors and their cost) in an effort to increase CGM applications among non-insulin dependent people. To meet this objective, this preliminary work has developed a methodology to mathematically infer BGC from measurements of non-invasive input variables which can be thought of as a “virtual” or “soft” sensor approach. In this work virtual sensors are developed and evaluated on 20 subjects using four BGC measurements per day and eight input variables representing meals, activity, stress, and clock time. Up to four weeks of data are collected for each subject. One evaluation consists of 3 days of training and up to 25 days of testing data. The second one consists of one week of training, one week of validation, and 2 weeks of testing data. The third one consists two weeks of training, one week of validation and one week of testing data. Model acceptability is determined on an individual basis based on the fitted correlation to CGM testing data. For 3 day, 1 week, and 2 weeks training studies, 35%, 55% and 65% of the subjects, respectively, met the Acceptability Criteria that we established based on the concept of usefulness.

Comments

This article is published as Rollins DK, Beverlin L, Mei Y, Kotz K, Andre D, Vyas N, Welk G, Franke WD. The development of a virtual sensor in glucose monitoring for non-insulin dependent people. Bioinformatics and Diabetes. 2014:1, 19; doi:10.14302;issn.2374-9431.jbd-13-283. Posted with permission.

Copyright Owner

Open Access Pub

Language

en

File Format

application/pdf

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