Campus Units

Kinesiology

Document Type

Article

Publication Version

Published Version

Publication Date

3-11-2016

Journal or Book Title

Journal of Biological Chemistry

Volume

291

Issue

11

First Page

5664

Last Page

5675

DOI

10.1074/jbc.M115.696849

Abstract

Background: Diminished activity of the enzyme AMP-activated protein kinase (AMPK) is associated with impaired insulin signaling.

Results: Protein Kinase (PK)C/D1 activation inhibits AMPK2 via Ser491 phosphorylation; PKD1 inhibition prevents this in skeletal muscle cells.

Conclusion: PKD1 is a novel upstream AMPK-kinase that phosphorylates AMPK on Ser491 and regulates insulin signaling.

Significance: PKD1 inhibition may be a novel strategy for improving insulin sensitivity.

Comments

This article is published as Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 inhibits AMPKα2 through phosphorylation of Ser491 and impairs insulin signaling in skeletal muscle cells. Journal Biological Chemistry. 2016; 291(11):5664-75. DOI: 10.1074/jbc.M115.696849. Posted with permission.

Copyright Owner

The American Society for Biochemistry and Molecular Biology, Inc.

Language

en

File Format

application/pdf

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