Campus Units
Kinesiology
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
3-2019
Journal or Book Title
Medicine & Science in Sports & Exercise
Volume
51
Issue
3
First Page
499
Last Page
508
DOI
10.1249/MSS.0000000000001822
Abstract
Purpose: Resistance exercise (RE) can improve many cardiovascular disease (CVD) risk factors, but specific data on the effects on CVD events and mortality are lacking. We investigated the associations of RE with CVD and all-cause mortality and further examined the mediation effect of body mass index (BMI) between RE and CVD outcomes.
Methods: We included 12,591 participants (mean age, 47 yr) who received at least two clinical examinations 1987-2006. RE was assessed by a self-reported medical history questionnaire.
Results: During a mean follow-up of 5.4 and 10.5 yr, 205 total CVD events (morbidity and mortality combined) and 276 all-cause deaths occurred, respectively. Compared with no RE, weekly RE frequencies of one, two, three times or total amount of 1-59 min were associated with approximately 40%-70% decreased risk of total CVD events, independent of aerobic exercise (AE) (all P values <0.05). However, there was no significant risk reduction for higher weekly RE of more than four times or ≥60 min. Similar results were observed for CVD morbidity and all-cause mortality. In the stratified analyses by AE, weekly RE of one time or 1-59 min was associated with lower risks of total CVD events and CVD morbidity regardless of meeting the AE guidelines. Our mediation analysis showed that RE was associated with the risk of total CVD events in two ways: RE had a direct U-shaped association with CVD risk (P value for quadratic trend <0.001) and RE indirectly lowered CVD risk by decreasing BMI.
Conclusion: Even one time or less than 1 h·wk of RE, independent of AE, is associated with reduced risks of CVD and all-cause mortality. BMI mediates the association of RE with total CVD events.
Copyright Owner
Lippincott, Williams & Wilkins
Copyright Date
2019
Language
en
File Format
application/pdf
Recommended Citation
Lui, Yanghui; Lee, Duck-Chul; Li, Yehua; Zhu, Weicheng; Zhang, Riquan; Sui, Xuemei; Lavie, Carl J.; and Blair, Steven N., "Associations of Resistance Exercise with Cardiovascular Disease Morbidity and Mortality" (2019). Kinesiology Publications. 77.
https://lib.dr.iastate.edu/kin_pubs/77
Included in
Exercise Science Commons, Expeditionary Education Commons, Psychology of Movement Commons
Comments
This accepted article is published as Liu Y, Lee DC (corresponding author), Li Y, Zhu W, Zhang R, Sui X, Lavie CJ, Blair SN. Associations of Resistance Exercise with Cardiovascular Disease Morbidity and Mortality. Med Sci Sports Exerc. 2019;51(3):499-508. doi:10.1249/MSS.0000000000001822. Posted with permission.