Campus Units

Biochemistry, Biophysics and Molecular Biology, Chemical and Biological Engineering, Genetics, Development and Cell Biology, Mathematics

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2012

Journal or Book Title

Mathematical Biosciences

Volume

238

Issue

2

First Page

65

Last Page

79

DOI

10.1016/j.mbs.2012.04.001

Abstract

The biological hypothesis that the astrocyte-secreted cytokine, interleukin-6 (IL6), stimulates differentiation of adult rat hippocampal progenitor cells (AHPCs) is considered from a mathematical perspective. The proposed mathematical model includes two different mechanisms for stimulation and is based on mass–action kinetics. Both biological mechanisms involve sequential binding, with one pathway solely utilizing surface receptors while the other pathway also involves soluble receptors. Choosing biologically-reasonable values for parameters, simulations of the mathematical model show good agreement with experimental results. A global sensitivity analysis is also conducted to determine both the most influential and non-influential parameters on cellular differentiation, providing additional insights into the biological mechanisms.

Comments

This is a manuscript of an article from Mathematical Biosciences 238 (2012): 65, doi:10.1016/j.mbs.2012.04.001. Posted with permission.

Rights

This is an open access article distributed under the Creative Commons BY-NC-ND License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, not used commercially, and is not changed in any way.

Copyright Owner

Elsevier Inc.

Language

en

File Format

application/pdf

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