Campus Units

Mechanical Engineering

Document Type

Article

Publication Version

Published Version

Publication Date

5-2018

Journal or Book Title

Biointerphases

Volume

13

Issue

3

First Page

03C402

DOI

10.1116/1.5022303

Abstract

Optical detection and conformational mapping of aptamers are important for improving medical and biosensing technologies and for better understanding of biological processes at the molecular level. The authors investigate the vibrational signals of deoxyribonucleic acid aptamers specific to Listeria monocytogenes immobilized on gold substrates using tip-enhanced Raman scattering (TERS) spectroscopy and nanoscale imaging. The authors compare topographic and nano-optical signals and investigate the fluctuations of the position-dependent TERS spectra. They perform spatial TERS mapping with 3 nm step size and discuss the limitation of the resulting spatial resolution under the ambient conditions. TERS mapping provides information about the chemical composition and conformation of aptamers and paves the way to future label-free biosensing.

Comments

This article is published as He, Siyu, Hongyuan Li, Carmen L. Gomes, and Dmitri V. Voronine. "Tip-enhanced Raman scattering of DNA aptamers for Listeria monocytogenes." Biointerphases 13, no. 3 (2018): 03C402. DOI: 10.1116/1.5022303. Posted with permission.

Copyright Owner

American Physical Society

Language

en

File Format

application/pdf

Available for download on Wednesday, May 01, 2019

Share

COinS