Campus Units
Mechanical Engineering, Center for Advanced Host Defenses, Immunobiotics and Translational Comparative Medicine
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
7-15-2015
Journal or Book Title
Advanced Healthcare Materials
Volume
4
Issue
10
First Page
1426
Last Page
1450
DOI
10.1002/adhm.201500040
Abstract
In recent years, the exploitation of phenomena surrounding microfluidics has seen an increase in popularity, as researchers have found a way to use their unique properties to create superior design alternatives. One such application is representing the properties and functions of different organs on a microscale chip for the purpose of drug testing or tissue engineering. With the introduction of “organ‐on‐a‐chip” systems, researchers have proposed various methods on various organ‐on‐a‐chip systems to mimic their in vivo counterparts. In this article, a systematic approach is taken to review current technologies pertaining to organ‐on‐a‐chip systems. Design processes with attention to the particular instruments, cells, and materials used are presented.
Copyright Owner
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Copyright Date
2015
Language
en
File Format
application/pdf
Recommended Citation
Caplin, Jeremy D.; Granados, Norma G.; James, Myra R.; Montazami, Reza; and Hashemi, Nicole Nastaran, "Microfluidic Organ‐on‐a‐Chip Technology for Advancement of Drug Development and Toxicology" (2015). Mechanical Engineering Publications. 313.
https://lib.dr.iastate.edu/me_pubs/313
Included in
Biomechanical Engineering Commons, Medical Toxicology Commons, Pharmaceutics and Drug Design Commons
Comments
This is the peer-reviewed version of the following article: Caplin, Jeremy D., Norma G. Granados, Myra R. James, Reza Montazami, and Nastaran Hashemi. "Microfluidic organ‐on‐a‐chip technology for advancement of drug development and toxicology." Advanced Healthcare Materials 4, no. 10 (2015): 1426-1450, which has been published in final form at DOI: 10.1002/adhm.201500040. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.