Campus Units

Mechanical Engineering, Center for Advanced Host Defenses, Immunobiotics and Translational Comparative Medicine

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

7-15-2015

Journal or Book Title

Advanced Healthcare Materials

Volume

4

Issue

10

First Page

1426

Last Page

1450

DOI

10.1002/adhm.201500040

Abstract

In recent years, the exploitation of phenomena surrounding microfluidics has seen an increase in popularity, as researchers have found a way to use their unique properties to create superior design alternatives. One such application is representing the properties and functions of different organs on a microscale chip for the purpose of drug testing or tissue engineering. With the introduction of “organ‐on‐a‐chip” systems, researchers have proposed various methods on various organ‐on‐a‐chip systems to mimic their in vivo counterparts. In this article, a systematic approach is taken to review current technologies pertaining to organ‐on‐a‐chip systems. Design processes with attention to the particular instruments, cells, and materials used are presented.

Comments

This is the peer-reviewed version of the following article: Caplin, Jeremy D., Norma G. Granados, Myra R. James, Reza Montazami, and Nastaran Hashemi. "Microfluidic organ‐on‐a‐chip technology for advancement of drug development and toxicology." Advanced Healthcare Materials 4, no. 10 (2015): 1426-1450, which has been published in final form at DOI: 10.1002/adhm.201500040. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.

Copyright Owner

WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Language

en

File Format

application/pdf

Published Version

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