Mechanical Engineering, Center for Advanced Host Defenses, Immunobiotics and Translational Comparative Medicine
Journal or Book Title
ACS Biomaterials Science and Engineering
The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro- and nanofibers for this purpose. The reasons for this growing interest include these materials’ high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning, microfluidics, wet spinning, rotary spinning, and self-assembly for drug delivery purposes. Additionally, we discuss the potential to use these fiber based systems in research and clinical applications.
American Chemical Society
Sharifi, Farrokh; Sooriyarachchi, Avinash C.; Altural, Hayriye; Montazami, Reza; Rylander, Marissa Nichole; and Hashemi, Nicole Nastaran, "Fiber Based Approaches as Medicine Delivery Systems" (2016). Mechanical Engineering Publications. 316.
Biology and Biomimetic Materials Commons, Biomaterials Commons, Biomechanical Engineering Commons, Biomechanics and Biotransport Commons, Nanoscience and Nanotechnology Commons, Polymer and Organic Materials Commons