Campus Units

Mechanical Engineering

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

10-15-2019

Journal or Book Title

Food Chemistry

Volume

295

First Page

671

Last Page

679

DOI

10.1016/j.foodchem.2019.05.165

Abstract

The aim of this work was to develop and optimize a pH-responsive nanoparticle based on poly(D,L-lactide-co-glycolide) (PLGA) and chitosan (CHIT) for delivery of natural antimicrobial using trans-cinnamaldehyde (TCIN) as a model compound. The optimization was performed using a central composite design and the desirability function approach. The optimized levels of variables considering all significant responses were 4% (w/w) of TCIN and 6.75% (w/w) of CHIT. After, optimized nanoparticles were produced and characterized according to their physicochemical properties and their antimicrobial activity against SalmonellaTyphimurium and Staphylococcus aureus. Optimized nanoparticles characterization indicated a satisfactory TCIN encapsulation (33.20 ± 0.85%), spherical shape, pH-responsive controlled release, with faster release in the presence of CHIT at low pH, and enhanced antimicrobial activity against both pathogens. TCIN encapsulation using PLGA coated with CHIT enhanced its antimicrobial activity and generated a delivery system with pH-sensitivity for controlled release with promising properties for food safety applications.

Comments

This is a manuscript of an article published as Pola, Cícero C., Allan RF Moraes, Eber AA Medeiros, Reinaldo F. Teófilo, Nilda FF Soares, and Carmen L. Gomes. "Development and optimization of pH-responsive PLGA-chitosan nanoparticles for triggered release of antimicrobials." Food Chemistry 295 (2019): 671-679. DOI: 10.1016/j.foodchem.2019.05.165. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

Elsevier Ltd.

Language

en

File Format

application/pdf

Available for download on Sunday, May 24, 2020

Published Version

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