Campus Units

Mechanical Engineering, Neuroscience

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

9-2019

Journal or Book Title

Journal of the Mechanical Behavior of Biomedical Materials

Volume

97

First Page

355

Last Page

364

DOI

10.1016/j.jmbbm.2019.05.028

Abstract

Traumatic brain injuries (TBI) affect millions of people each year and can result in long-term difficulties in thinking or focusing. Due to the number of people affected by these injuries, significant research has been dedicated to determining the mechanical properties of the brain using postmortem tissue from animals harvested within 24 h. The postmortem brain tissue is often stored in a solution until a rheological experiment is ready to begin. However, the effect of storage duration on the mechanical behavior of brain tissue is not understood. In this paper, postmortem porcine brains were placed in normal saline solution (0.9% NaCl) and refrigerated between 30 min and 6.5 h to allow the brain to absorb the solution. Afterwards, samples from both soaked and freshly extracted brains were subjected to unconfined compression tests at compressive rates of 5, 50, and 500 mm/min. The fractional Zener viscoelastic model was applied to obtain the brain's mechanical properties. While the results did not show a significant relationship between absorption and the long-term stiffness (E), both the relaxation time (τ0) and fractional order (α) were statistically influenced by both the length of time in the solution and compressive rate. Further, the instantaneous stiffness (E0) was statistically influenced by the length of time in solution, though not the compressive rate.

Comments

This is a manuscript of an article published as McCarty, Annastacia K., Ling Zhang, Sarah Hansen, William J. Jackson, and Sarah A. Bentil. "Influence of saline solution absorption and compressive rate on the material properties of brain tissue." Journal of the Mechanical Behavior of Biomedical Materials 97 (2019): 355-364. DOI: 10.1016/j.jmbbm.2019.05.028. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

Elsevier Ltd.

Language

en

File Format

application/pdf

Available for download on Sunday, May 23, 2021

Published Version

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