Campus Units

Mechanical Engineering, Neuroscience

Document Type

Article

Publication Version

Submitted Manuscript

Publication Date

12-2019

Journal or Book Title

Journal of the Mechanical Behavior of Biomedical Materials

Volume

100

First Page

103380

DOI

10.1016/j.jmbbm.2019.103380

Abstract

Traumatic brain injuries (TBI) affect millions of people each year. While research has been dedicated to determining the mechanical properties of the uninjured brain, there has been a lack of investigation on the mechanical properties of the brain after experiencing a primary blast-induced TBI. In this paper, whole porcine brains were exposed to a shock wave to simulate blast-induced TBI. First, ten (10) brains were subjected to unconfined compression experiments immediately following shock wave exposure. In addition, 22 brains exposed to a shock wave were placed in saline solution and refrigerated between 30 minutes and 6.0 hours before undergoing unconfined compression experiments. This study aimed to investigate the effect of a time delay on the viscoelastic properties in the event that an experiment cannot be completed immediately. Samples from both soaked and freshly extracted brains were subjected to compressive rates of 5, 50, and 500 mm/min during the unconfined compression experiments. The fractional Zener (FZ) viscoelastic model was applied to obtain the brain's material properties. The length of time in the solution statistically influenced three of the four FZ coefficients, E0 (instantaneous elastic response), τ0 (relaxation time), and α (fractional order). Further, the compressive rate statistically influenced τ0 and α.

Comments

This is a manuscript of an article published as McCarty, Annastacia K., Ling Zhang, Sarah Hansen, William J. Jackson, and Sarah A. Bentil. "Viscoelastic properties of shock wave exposed brain tissue subjected to unconfined compression experiments." Journal of the Mechanical Behavior of Biomedical Materials (2019): 103380. DOI: 10.1016/j.jmbbm.2019.103380. Posted with permission.

Copyright Owner

Elsevier Ltd.

Language

en

File Format

application/pdf

Published Version

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