Campus Units

Mechanical Engineering, Biomedical Sciences, Ames Laboratory, Bioeconomy Institute (BEI)

Document Type

Article

Publication Version

Published Version

Publication Date

10-21-2019

Journal or Book Title

Analytical Methods

Volume

11

Issue

39

First Page

4953

Last Page

5072

DOI

10.1039/C9AY01576K

Abstract

Traumatic brain injuries (TBIs) are complex phenomena that create epidemic healthcare and financial concerns. Recent studies have theorized that cavitation exists during a TBI and has potential to induce significant damage to the surrounding anatomy. This study seeks to implement polydimethylsiloxane (PDMS) films as a placeholder of the brain to elucidate the damage that the surrounding brain tissue would experience from nearby cavitation. The apparatus includes an existing methodology that implements controlled cavitation. 3D confocal microscopy and interferometry techniques are used to characterize the surface damage to the PDMS films. Visual representation and roughness parameters on the nanoscale help elucidate a distinct difference between control and experimental samples. These results help legitimize the concern of cavitation in the skull and also help motivate future studies to analyze the cellular response to surrounding cavitation.

Comments

This article is published as Wrede, Alex H., Faisal Al-Masri, Reza Montazami, and Nicole N. Hashemi. "Investigation of cavitation-induced damage on PDMS films." Analytical Methods 11, no. 39 (2019): 5038-5043. DOI: 10.1039/C9AY01576K. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

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