Manufacturing of poly(ethylene glycol diacrylate)-based hollow microvessels using microfluidics
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Abstract
The microvasculature is a vital organ that distributes nutrients within tissues, and collects waste products from them, and which defines the environmental conditions in both normal and disease situations. Here, a microfluidic chip was developed for the fabrication of poly(ethylene glycol diacrylate) (PEGDA)-based hollow self-standing microvessels having inner dimensions ranging from 15 μm to 73 μm and displaying biocompatibility/cytocompatibility. Macromer solutions were hydrodynamically focused into a single microchannel to form a concentric flow regime, and were subsequently solidified through photopolymerization. This approach uniquely allowed the fabrication of hollow microvessels having a defined structure and integrity suitable for cell culturing.
Comments
This article is published as Aykar, Saurabh S., David E. Reynolds, Marilyn C. McNamara, and Nicole N. Hashemi. "Manufacturing of poly(ethylene glycol diacrylate)-based hollow microvessels using microfluidics." RSC Advances 10, no. 7 (2020): 4095-4102. DOI: 10.1039/C9RA10264G. Posted with permission.