Campus Units

Biomedical Sciences, Ames Laboratory, Bioeconomy Institute (BEI), Mechanical Engineering

Document Type

Article

Publication Version

Published Version

Publication Date

1-24-2020

Journal or Book Title

RSC Advances

Volume

10

Issue

7

First Page

4095

Last Page

4102

DOI

10.1039/C9RA10264G

Abstract

The microvasculature is a vital organ that distributes nutrients within tissues, and collects waste products from them, and which defines the environmental conditions in both normal and disease situations. Here, a microfluidic chip was developed for the fabrication of poly(ethylene glycol diacrylate) (PEGDA)-based hollow self-standing microvessels having inner dimensions ranging from 15 μm to 73 μm and displaying biocompatibility/cytocompatibility. Macromer solutions were hydrodynamically focused into a single microchannel to form a concentric flow regime, and were subsequently solidified through photopolymerization. This approach uniquely allowed the fabrication of hollow microvessels having a defined structure and integrity suitable for cell culturing.

Comments

This article is published as Aykar, Saurabh S., David E. Reynolds, Marilyn C. McNamara, and Nicole N. Hashemi. "Manufacturing of poly(ethylene glycol diacrylate)-based hollow microvessels using microfluidics." RSC Advances 10, no. 7 (2020): 4095-4102. DOI: 10.1039/C9RA10264G. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

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