Campus Units

Mechanical Engineering, Biomedical Sciences, Ames Laboratory, Bioeconomy Institute (BEI), Computer Science, Chemical and Biological Engineering

Document Type

Article

Publication Version

Published Version

Publication Date

3-19-2020

Journal or Book Title

Frontiers in Materials

Volume

7

First Page

61

DOI

10.3389/fmats.2020.00061

Abstract

Microfluidically manufacturing graphene-alginate microfibers create possibilities for encapsulating rat neural cells within conductive 3D tissue scaffolding to enable the creation of real-time 3D sensing arrays with high physiological relavancy. Cells are encapsulated using the biopolymer alginate, which is combined with graphene to create a cell-containing hydrogel with increased electrical conductivity. Resulting novel alginate-graphene microfibers showed a 2.5-fold increase over pure alginate microfibers, but did not show significant differences in size and porosity. Cells encapsulated within the microfibers survive for up to 8 days, and maintain ~20% live cells over that duration. The biocompatible aqueous graphene suspension used in this investigation was obtained via liquid phase exfoliation of pristine graphite, to create a graphene-alginate pre-hydrogel solution.

Comments

This article is published as McNamara, Marilyn C., Niaraki Asli, Amir Ehsan, Jingshuai Guo, Jasmin Okuzono, Reza Montazami, and Nicole N. Hashemi. "Enhancing the Conductivity of Cell-Laden Alginate Microfibers with Aqueous Graphene for Neural Applications." Frontiers in Materials 7 (2020): 61. DOI: 10.3389/fmats.2020.00061. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

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