Campus Units

Mechanical Engineering, Biomedical Sciences, Ames Laboratory, Bioeconomy Institute (BEI)

Document Type


Publication Version

Accepted Manuscript

Publication Date


Journal or Book Title

Progress in Biomedical Engineering




Traumatic brain injury and other neurological disorders continue to affect many worldwide and demand further research. It has been shown that electrical signaling and ion channel flow and dynamics are disrupted over the course of a traumatic brain injury as well as over the course of other neurological disorders. However, typical devices used to measure ion flow and electrical signaling from the brain suffer from complexity, high expense, poor spacial and temporal resolution, and low signal to noise ratios (SNRs). Graphene has emerged as an economical and simple alternative to sensing electrical and ionic signals in a variety of biological situations. This material has emerged as a power material due to its excellent strength, electrical conductivity, and biocompatibility. This review paper focuses on the advantages of the different graphene–based electronic devices and how these devices are being developed into biosensors capable of sensing neuronal ionic and electrical activity and activity from other electrically excitable cells.


This is the Accepted Manuscript version of an article accepted for publication in Progress in Biomedical Engineering. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at DOI: 10.1088/2516-1091/abe55b. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Copyright Owner

IOP Publishing Ltd.



File Format


Available for download on Friday, February 11, 2022

Published Version