Campus Units
Materials Science and Engineering
Document Type
Article
Publication Version
Published Version
Publication Date
2015
Journal or Book Title
RSC Advances
Volume
5
First Page
597
Last Page
607
DOI
10.1039/C4RA13506G
Abstract
Incompatible organic reactions impede efficient green synthesis by making multi-component or cascade reactions a big challenge. This review highlights pot-in-pot reactions (multiple reactions carried out in one pot by separating key reactions with a thin polymeric membrane) as an efficient, green synthetic alternative to conventional synthesis. We discuss the advantages of homogeneous processes to develop new cascade reaction sequences by reviewing the use of polymeric thimbles as selective semi-permeable walls. These thimbles allow small organic molecules to diffuse through while retaining polar reagents, polar solvents, and/or organometallic catalysts. The dynamic and versatile nature of this technique is demonstrated by performing 2- and 3-step cascade reactions in one glass pot. A pot-in-pot reaction approach to synthesis circumvents the need to isolate intermediates, or handling of toxic/unpleasant by-products, therefore enabling synthesis of otherwise challenging molecules, improving the efficiency, or enabling greener approaches to modular synthesis.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright Owner
The Royal Society of Chemistry
Copyright Date
2015
Language
en
File Format
application/pdf
Recommended Citation
Atkinson, M. B.J.; Oyola-Reynoso, Stephanie; Luna, R. E.; Bwambok, D. K.; and Thuo, Martin M., "Pot-in-pot reactions: a simple and green approach to efficient organic synthesis" (2015). Materials Science and Engineering Publications. 229.
https://lib.dr.iastate.edu/mse_pubs/229
Included in
Biochemical and Biomolecular Engineering Commons, Membrane Science Commons, Polymer and Organic Materials Commons
Comments
This article is published as Atkinson, M. B. J., S. Oyola-Reynoso, R. E. Luna, D. K. Bwambok, and M. M. Thuo. "Pot-in-pot reactions: a simple and green approach to efficient organic synthesis." RSC Advances 5, no. 1 (2015): 597-607, doi:10.1039/C4RA13506G. Posted with permission.