Campus Units

Materials Science and Engineering

Document Type

Article

Publication Version

Published Version

Publication Date

2015

Journal or Book Title

RSC Advances

Volume

5

First Page

597

Last Page

607

DOI

10.1039/C4RA13506G

Abstract

Incompatible organic reactions impede efficient green synthesis by making multi-component or cascade reactions a big challenge. This review highlights pot-in-pot reactions (multiple reactions carried out in one pot by separating key reactions with a thin polymeric membrane) as an efficient, green synthetic alternative to conventional synthesis. We discuss the advantages of homogeneous processes to develop new cascade reaction sequences by reviewing the use of polymeric thimbles as selective semi-permeable walls. These thimbles allow small organic molecules to diffuse through while retaining polar reagents, polar solvents, and/or organometallic catalysts. The dynamic and versatile nature of this technique is demonstrated by performing 2- and 3-step cascade reactions in one glass pot. A pot-in-pot reaction approach to synthesis circumvents the need to isolate intermediates, or handling of toxic/unpleasant by-products, therefore enabling synthesis of otherwise challenging molecules, improving the efficiency, or enabling greener approaches to modular synthesis.

Comments

This article is published as Atkinson, M. B. J., S. Oyola-Reynoso, R. E. Luna, D. K. Bwambok, and M. M. Thuo. "Pot-in-pot reactions: a simple and green approach to efficient organic synthesis." RSC Advances 5, no. 1 (2015): 597-607, doi:10.1039/C4RA13506G. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

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