Campus Units

Chemical and Biological Engineering, Materials Science and Engineering, Ames Laboratory

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2013

Journal or Book Title

Advanced Healthcare Materials

Volume

2

Issue

5

First Page

667

Last Page

672

DOI

10.1002/adhm.201200341

Abstract

Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core–shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

Comments

This is the peer reviewed version of the following article: Ma, M., Chiu, A., Sahay, G., Doloff, J. C., Dholakia, N., Thakrar, R., Cohen, J., Vegas, A., Chen, D., Bratlie, K. M., Dang, T., York, R. L., Hollister-Lock, J., Weir, G. C. and Anderson, D. G. (2013), Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation. Advanced Healthcare Materials, 2: 667–672, which has been published in final form at doi:10.1002/adhm.201200341. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.

Copyright Owner

WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Language

en

File Format

application/pdf

Published Version

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