Campus Units
Chemical and Biological Engineering, Materials Science and Engineering, Ames Laboratory
Document Type
Article
Publication Version
Published Version
Publication Date
2014
Journal or Book Title
Biomacromolecules
Volume
15
Issue
11
First Page
4102
Last Page
4110
DOI
10.1021/bm5011382
Abstract
Material properties play a key role in the cellular internalization of polymeric particles. In the present study, we have investigated the effects of material characteristics such as water contact angle, zeta potential, melting temperature, and alternative activation of complement on particle internalization for pro-inflammatory, pro-angiogenic, and naïve macrophages by using biopolymers (∼600 nm), functionalized with 13 different molecules. Understanding how material parameters influence particle internalization for different macrophage phenotypes is important for targeted delivery to specific cell populations. Here, we demonstrate that material parameters affect the alternative pathway of complement activation as well as particle internalization for different macrophage phenotypes. Here, we show that the quantitative structure–activity relationship method (QSAR) previously used to predict physiochemical properties of materials can be applied to targeting different macrophage phenotypes. These findings demonstrated that targeted drug delivery to macrophages could be achieved by exploiting material parameters.
Copyright Owner
American Chemical Society
Copyright Date
2014
Language
en
File Format
application/pdf
Recommended Citation
Wang, Daniel; Phan, Ngoc; Isely, Christopher; Bruene, Lucas; and Bratlie, Kaitlin M., "Effect of Surface Modification and Macrophage Phenotype on Particle Internalization" (2014). Materials Science and Engineering Publications. 242.
https://lib.dr.iastate.edu/mse_pubs/242
Included in
Biochemical and Biomolecular Engineering Commons, Biology and Biomimetic Materials Commons, Membrane Science Commons, Molecular, Cellular, and Tissue Engineering Commons, Polymer and Organic Materials Commons
Comments
Reprinted with permission from Wang, Daniel, Ngoc Phan, Christopher Isely, Lucas Bruene, and Kaitlin M. Bratlie. "Effect of surface modification and macrophage phenotype on particle internalization." Biomacromolecules 15, no. 11 (2014): 4102-4110, doi:10.1021/bm5011382. Copyright 2014 American Chemical Society.