Campus Units

Chemical and Biological Engineering, Materials Science and Engineering, Ames Laboratory

Document Type

Article

Publication Version

Published Version

Publication Date

2014

Journal or Book Title

Biomacromolecules

Volume

15

Issue

11

First Page

4102

Last Page

4110

DOI

10.1021/bm5011382

Abstract

Material properties play a key role in the cellular internalization of polymeric particles. In the present study, we have investigated the effects of material characteristics such as water contact angle, zeta potential, melting temperature, and alternative activation of complement on particle internalization for pro-inflammatory, pro-angiogenic, and naïve macrophages by using biopolymers (∼600 nm), functionalized with 13 different molecules. Understanding how material parameters influence particle internalization for different macrophage phenotypes is important for targeted delivery to specific cell populations. Here, we demonstrate that material parameters affect the alternative pathway of complement activation as well as particle internalization for different macrophage phenotypes. Here, we show that the quantitative structure–activity relationship method (QSAR) previously used to predict physiochemical properties of materials can be applied to targeting different macrophage phenotypes. These findings demonstrated that targeted drug delivery to macrophages could be achieved by exploiting material parameters.

Comments

Reprinted with permission from Wang, Daniel, Ngoc Phan, Christopher Isely, Lucas Bruene, and Kaitlin M. Bratlie. "Effect of surface modification and macrophage phenotype on particle internalization." Biomacromolecules 15, no. 11 (2014): 4102-4110, doi:10.1021/bm5011382. Copyright 2014 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

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