Campus Units

Chemical and Biological Engineering, Materials Science and Engineering, Ames Laboratory

Document Type

Article

Publication Version

Published Version

Publication Date

2014

Journal or Book Title

Clinical and Translational Medicine

Volume

3

Issue

1

First Page

62

DOI

10.1186/s40169-014-0041-2

Abstract

Macrophages have long been known to exhibit heterogeneous and plastic phenotypes. They show functional diversity with roles in homeostasis, tissue repair, immunity and disease. There exists a spectrum of macrophage phenotypes with varied effector functions, molecular determinants, cytokine and chemokine profiles, as well as receptor expression. In tumor microenvironments, the subset of macrophages known as tumor-associated macrophages generates byproducts that enhance tumor growth and angiogenesis, making them attractive targets for anti-cancer therapeutics. With respect to wound healing and the foreign body response, there is a necessity for balance between pro-inflammatory, wound healing, and regulatory macrophages in order to achieve successful implantation of a scaffold for tissue engineering. In this review, we discuss the multitude of ways macrophages are known to be important in cancer therapies and implanted biomaterials.

Comments

This article is published as Bygd, Hannah C., Kiva D. Forsmark, and Kaitlin M. Bratlie. "The significance of macrophage phenotype in cancer and biomaterials." Clinical and translational medicine 3, no. 1 (2014): 62, doi:10.1186/s40169-014-0041-2. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

Bygd et al.

Language

en

File Format

application/pdf

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