Campus Units
Chemical and Biological Engineering, Materials Science and Engineering, Ames Laboratory
Document Type
Article
Publication Version
Published Version
Publication Date
2015
Journal or Book Title
ACS Biomaterials Science & Engineering
Volume
1
Issue
3
First Page
166
Last Page
174
DOI
10.1021/ab5001063
Abstract
Of central importance to tissue engineering and drug delivery is identifying polymer parameters that increase or decrease specific cytokines in response to biomaterials. In this study, we have interrogated the effects of material descriptors and material characteristics on pro-inflammatory, pro-angiogenic, and naïve macrophages using polymeric particles (∼600 nm), functionalized with 13 different moieties. We characterized tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) secretion for the three macrophage populations and used the quantitative structure–activity relationship method (QSAR) to accurately predict cytokine secretion for the different macrophage phenotypes. The findings presented here demonstrate that altering cellular responses to polymers can be achieved through exploiting material parameters. For pro-inflammatory macrophages, polarity and the ability to hydrogen bond appear to significantly impact TNF-α secretion while charge impacted pro-angiogenic macrophages. Naïve cells were impacted by charge in a similar manner as the pro-angiogenic cells; however, hydrophilicity also increased TNF-α secretion in these cells. For IL-10 secretion, hydrogen bonding was very negatively correlated with pro-inflammatory cells, whereas it was positively correlated with pro-angiogenic cells.
Copyright Owner
American Chemical Society
Copyright Date
2015
Language
en
File Format
application/pdf
Recommended Citation
Wang, Daniel and Bratlie, Kaitlin M., "Influence of Polymer Chemistry on Cytokine Secretion from Polarized Macrophages" (2015). Materials Science and Engineering Publications. 244.
https://lib.dr.iastate.edu/mse_pubs/244
Included in
Biochemical and Biomolecular Engineering Commons, Biology and Biomimetic Materials Commons, Polymer and Organic Materials Commons
Comments
Reprinted with permission from Wang, Daniel, and Kaitlin M. Bratlie. "Influence of polymer chemistry on cytokine secretion from polarized macrophages." ACS Biomaterials Science & Engineering 1, no. 3 (2015): 166-174, doi:10.1021/ab5001063. Copyright 2015 American Chemical Society.