Campus Units

Materials Science and Engineering, Chemical and Biological Engineering

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2016

Journal or Book Title

Nature Biotechnology

Volume

34

Issue

3

First Page

345

Last Page

352

DOI

10.1038%2Fnbt.3462

Abstract

The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient16. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to the utility of the compounds reported here, our approach may enable the discovery of other materials that mitigate the foreign body response.

Comments

This is a manuscript of an article published as Vegas, Arturo J., Omid Veiseh, Joshua C. Doloff, Minglin Ma, Hok Hei Tam, Kaitlin Bratlie, Jie Li et al. "Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates." Nature Biotechnology 34, no. 3 (2016): 345, doi:10.1038%2Fnbt.3462. Posted with permission.

Copyright Owner

Nature America, Inc.

Language

en

File Format

application/pdf

Published Version

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