For treatment of acne the glucuronide of retinoic acid (retinoyl β-glucuronide) is orally administered to women of child-bearing age who are capable of conception. This therapy is safer than the oral administration of retinoic acid because retinoic acid glucuronide is essentially non-teratogenic at dose levels effective for the acne treatment. The retinoic acid glucuronide can be in all-trans or 13-cis form.
ISURF Reference Number
Iowa State University Research Foundation, Inc.,
Barua, Arun B.; Gunning, Desiree; and Olson, James A., "Non-teratogenic vitamin A preparation for women of child-bearing age" (1991). Iowa State University Patents. 152.