A method of synthesizing nitrogen heterocycles such as indoles, indolines, oxindoles, quinolines, isoquinolines, and isoquinolones, all of which are pharmacologically active. The method involves cyclizing a haloaryl alkene in the presence of a catalytically effective amount of a palladium(II) ion source and in the presence of a cyclizing promoting base such as an alkali metal salt.
ISURF Reference Number
Iowa State University Research Foundation, Inc.,
Larock, Richard C. and Babu, Srinivasan, "Synthesis of nitrogen heterocycles" (1989). Iowa State University Patents. 199.