An artificial zona pellucida is provided for implantation in the peritoneal cavities of small laboratory animals. The assembly includes a hydrogel cartridge for containing one or more nude isolated blastomeres which can be cultured therein to an implant stage in the peritoneal cavity of a small animal such as a mouse. The combination is particularly advantageous for culturing of nude isolated blastomeres of a species different from the host small laboratory animal, such as blastomeres of domestic animals.
ISURF Reference Number
Iowa State University Research Foundation, Inc.,
Pineda, Mauricio H. and Pollard, John W., "Artificial zona pellucida for in vivo culture of nude blastomeres" (1993). Iowa State University Patents. 221.