Novel uses for diterpene modulators of macrophage phagosomal maturation are provided. The diterpene isotuberculosinol is used as an immune modulator, assay for pharmaceutical compositions and an isolated Mycobacterium tuberculosis labdane-related diterpenoid virulence factor. A method of treating Mycobacterium tuberculosis infectivity is further provided.
US 8,309,322 B2
Iowa State University Research Foundation, Inc.; Cornell University
Peters, Reuben J.; Russell, David G.; and Mann, Francis M., "Diterpene modulator of macrophage phagosomal maturation" (2012). Iowa State University Patents. 26.