The use of capillary electrophoresis (CE) has greatly improved DNA sequencing rates compared to conventional slab gel electrophoresis. Part of the improvement in speed, however, has been offset by the loss of the ability (inherent in slab gels) to accommodate multiple lanes in a single run. Highly multiplexed capillary electrophoresis, by making possible hundreds or even thousands of parallel sequencing runs, represents an attractive approach to overcoming the current throughput limitations of existing DNA sequencing instrumentation.
EP 1 109 014 B1
Iowa State University Research Foundation, Inc.
Yeung, Edward S.; Chang, Huang-Tsung; Fung, Eliza N.; Li, Qingbo; and Lu, Xiandan, "Multiplexed capillary electrophoresis system" (2010). Iowa State University Patents. 68.