Campus Units
Chemistry, Physics and Astronomy, Bioinformatics and Computational Biology
Document Type
Article
Publication Version
Published Version
Publication Date
2014
Journal or Book Title
PLoS One
Volume
9
Issue
6
First Page
1
Last Page
8
DOI
10.1371/journal.pone.0097903
Abstract
Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains, which are growing at an alarming rate. The MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps.
Rights
© 2014 Bolla et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright Owner
Bolla et al.
Copyright Date
2014
Language
en
File Format
application/pdf
Recommended Citation
Reddy Bolla, Jani; Su, Chih-Chia; Do, Sylvia V.; Radhakrishnan, Pattathil; Kumar, Nitin; Long, Feng; Chou, Tsung-Han; Delmar, Jared A.; Lei, Hsiang-Ting; Rajashankar, Kanagalaghatta R.; Shafer, William M.; and Yu, Edward, "Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump" (2014). Physics and Astronomy Publications. 168.
https://lib.dr.iastate.edu/physastro_pubs/168
Included in
Biochemistry Commons, Biological and Chemical Physics Commons, Biophysics Commons, Medicinal-Pharmaceutical Chemistry Commons
Comments
This article is from PLoS One 9 (2014): 1, doi:10.1371/journal.pone.0097903. Posted with permission.