Molecular, Cellular and Developmental Biology, Biochemistry, Biophysics and Molecular Biology, Physics and Astronomy
Journal or Book Title
Acta Crystallographica Section F
The Escherichia coli AcrR multidrug-binding protein represses transcription of acrAB and is induced by many structurally unrelated cytotoxic compounds. The crystal structure of AcrR in space group P2221 has been reported previously. This P2221 structure has provided direct information about the multidrug-binding site and important residues for drug recognition. Here, a crystal structure of this regulator in space group P31 is presented. Comparison of the two AcrR structures reveals possible mechanisms of ligand binding and AcrR regulation.
International Union of Crystallography
Gu, Ruoyu; Li, Ming; Su, Chih-Chia; Long, Feng; Routh, Matthew D.; Yang, Feng; McDermott, Gerry; and Yu, Edward, "Conformational change of the AcrR regulator reveals a possible mechanism of induction" (2008). Physics and Astronomy Publications. 170.