Campus Units

Genetics, Development and Cell Biology, Plant Pathology and Microbiology, Genome Informatics Facility

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

10-2016

Journal or Book Title

New Phytologist

Volume

212

Issue

2

First Page

444

Last Page

460

DOI

10.1111/nph.14047

Abstract

• Heterodera glycines, the soybean cyst nematode, delivers effector proteins into soybean roots to initiate and maintain an obligate parasitic relationship. HgGLAND18 encodes a candidate H. glycines effector and is expressed throughout the infection process.

• We used a combination of molecular, genetic, bioinformatic and phylogenetic analyses to determine the role of HgGLAND18 during H. glycines infection.

• HgGLAND18 is necessary for pathogenicity in compatible interactions with soybean. The encoded effector strongly suppresses both basal and hypersensitive cell death innate immune responses, and immunosuppression requires the presence and coordination between multiple protein domains. The N-terminal domain in HgGLAND18 contains unique sequence similarity to domains of an immunosuppressive effector of Plasmodium spp., the malaria parasites. The Plasmodium effector domains functionally complement the loss of the N-terminal domain from HgGLAND18.

• In-depth sequence searches and phylogenetic analyses demonstrate convergent evolution between effectors from divergent parasites of plants and animals as the cause of sequence and functional similarity.

Comments

This is the peer reviewed version of the following article: Noon, Jason B., Mingsheng Qi, Danielle N. Sill, Usha Muppirala, Sebastian Eves‐van den Akker, Thomas R. Maier, Drena Dobbs, Melissa G. Mitchum, Tarek Hewezi, and Thomas J. Baum. "A Plasmodium‐like virulence effector of the soybean cyst nematode suppresses plant innate immunity." New Phytologist 212, no. 2 (2016): 444-460, which has been published in final form at doi: 10.1111/nph.14047. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Copyright Owner

The Authors, New Phytologist, New Phytologist Trust

Language

en

File Format

application/pdf

Published Version

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