Location

Seattle, WA

Start Date

1-1-1996 12:00 AM

Description

In the development of pharmaceutical products the elastic parameters of excipients are studied to assume drug safety. The excipients and their coating affect the emission properties of the drug. To determine the elastic parameters, the powder bond material is first pressed into the shape of a rectangular beam. In commonly used 3-point bending measurements, there is a tendency to move from the elastic bending regime to the plastic bending regime which necessarily changes the result for the elastic parameter in question [1]. Another available method is based on photoacoustics, but it is limited to the elastic regime [2]. The goal of this study is to create a system that would allow for high accuracy testing of these materials from the low force elastic to high force plastic regimes while using the same apparatus.

Book Title

Review of Progress in Quantitative Nondestructive Evaluation

Volume

15B

Chapter

Chapter 5: Engineered Materials

Section

Biomedical Materials

Pages

1341-1346

DOI

10.1007/978-1-4613-0383-1_175

Language

en

File Format

application/pdf

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Jan 1st, 12:00 AM

Determination of Elastic Parameters of Pharmaceutical Materials Using a Fiber Interferometer

Seattle, WA

In the development of pharmaceutical products the elastic parameters of excipients are studied to assume drug safety. The excipients and their coating affect the emission properties of the drug. To determine the elastic parameters, the powder bond material is first pressed into the shape of a rectangular beam. In commonly used 3-point bending measurements, there is a tendency to move from the elastic bending regime to the plastic bending regime which necessarily changes the result for the elastic parameter in question [1]. Another available method is based on photoacoustics, but it is limited to the elastic regime [2]. The goal of this study is to create a system that would allow for high accuracy testing of these materials from the low force elastic to high force plastic regimes while using the same apparatus.