Degree Type

Dissertation

Date of Award

1993

Degree Name

Doctor of Philosophy

Department

Chemical and Biological Engineering

First Advisor

Mary Helen Greer

Second Advisor

Dennis C. Johnson

Abstract

This thesis describes the development of a dual-beam, fiber optic instrument for solution-phase analysis of thin-film sensors. Colorimetric indicators are described for incorporation into porous polymeric films. The films are immobilized at the distal ends of optical fibers and yield an optical response proportional to the target analyte. In its present form, the instrument functions in an absorbance mode as a solid-state, dual-wavelength photometer and is equipped with a custom-designed microprocessor controller and data processor. The described study encompasses interdisciplinary research in the fields of biomedical engineering, synthetic organic chemistry, interfacial chemistry, materials science, and computer and electrical engineering;The primary emphasis in development of thin-film sensors focused on pH. Other indicators are proposed for detecting calcium, potassium, and sodium. These ions are major physiological indicators of homeostasis; therefore, monitoring of these parameters is important in determining the clinical status of astronauts on long-term space missions.

DOI

https://doi.org/10.31274/rtd-180813-9598

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Shelley Jean Coldiron

Language

en

Proquest ID

AAI9334970

File Format

application/pdf

File Size

226 pages

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