Degree Type

Dissertation

Date of Award

1996

Degree Name

Doctor of Philosophy

Department

Chemistry

First Advisor

George A. Kraus

Abstract

The synthesis of angularly fused quinone natural product G-2N has been achieved using a photoenolization reaction and a Diels-Alder reaction in the key carbon-carbon bond forming steps. This route is direct and flexible. It should be applicable to synthesis of other analogous natural products;The skeleton of colchicine has been achieved using a Diels-Alder reaction followed by an electrophilic addition to the A ring as key steps. Our synthetic approach is direct. It could provide an efficient entry to total synthesis of colchicine.

DOI

https://doi.org/10.31274/rtd-180813-10396

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Guohua Zhao

Language

en

Proquest ID

AAI9626079

File Format

application/pdf

File Size

86 pages

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