Polymer chemistry effects on protein release and immune activation
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The function of the Department of Chemical and Biological Engineering has been to prepare students for the study and application of chemistry in industry. This focus has included preparation for employment in various industries as well as the development, design, and operation of equipment and processes within industry.Through the CBE Department, Iowa State University is nationally recognized for its initiatives in bioinformatics, biomaterials, bioproducts, metabolic/tissue engineering, multiphase computational fluid dynamics, advanced polymeric materials and nanostructured materials.
History
The Department of Chemical Engineering was founded in 1913 under the Department of Physics and Illuminating Engineering. From 1915 to 1931 it was jointly administered by the Divisions of Industrial Science and Engineering, and from 1931 onward it has been under the Division/College of Engineering. In 1928 it merged with Mining Engineering, and from 1973–1979 it merged with Nuclear Engineering. It became Chemical and Biological Engineering in 2005.
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1913 - present
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- Department of Chemical Engineering (1913–1928)
- Department of Chemical and Mining Engineering (1928–1957)
- Department of Chemical Engineering (1957–1973, 1979–2005)
- Department of Chemical and Biological Engineering (2005–present)
- College of Engineering(parent college)
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Abstract
The objective was to study the chemistry effect on protein release and stabilization and on immune cell activation using polyanhydrides. The two goals were to: (1) Determine how polyanhydride chemistry and fabrication methods affect the release kinetics of proteins from microspheres and the stability of the released protein. Microspheres were fabricated using two non-aqueous methods: solid/oil/oil and cryogenic atomization. Studies found no significant difference in release kinetics of ovalbumin. The more hydrophilic polyanhydrides showed more favorable protein stability, preserving both the immunological epitopes and the primary structure. (2) Investigate the surface marker expression of CD86, CD40, DC SIGN, and MHCII on dendritic cells by polyanhydride microspheres and study the effect of chemistry on activation pathways of these immune cells. All microspheres were shown to induce maturation of murine dendritic cells; the degree to which each surface marker tested was activated was a function of chemistry.