Degree Type

Thesis

Date of Award

2007

Degree Name

Master of Science

Department

Computer Science

First Advisor

Vasant Honavar

Second Advisor

David Fernandez-Baca

Third Advisor

Mary Greenlee

Abstract

Elucidation of interaction mechanisms between elements of complex biological systems often involves processing vast amounts of data, extracting meaningful information from heterogeneous data sources, generating, annotating, and refining research hypotheses. While various public databases, graphing software, and data mining methods are available, transferring data between these sources is not trivial. Limited support for querying is provided, and searching your own data along public datasets is often not possible. We developed Retina Workbench, a user-friendly software tool enabling biologists to easily store and manipulate public and private genetic data, query gene expression datasets and genetic networks based on the stored annotations as well as Gene Ontology annotations, and merge and reuse results obtained. Retina Workbench aided in our study of photoreceptor differentiation and development in mouse retina and showed to be a valuable tool automating the discovery and study of genetic regulatory networks.

DOI

https://doi.org/10.31274/rtd-180813-16204

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Oksana Kohutyuk

Language

en

Proquest ID

AAI1446069

OCLC Number

181100011

ISBN

9780549142348

File Format

application/pdf

File Size

82 pages

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