Date of Award
Master of Science
This longitudinal study was the first study to assess the effect of two different kinds of exercise on levels of proinflammatory cytokines in PBMC and serum. IL-1beta, TNF-alpha and IL-6 levels were measured using regular ELISA assay in PBMC; IL-6 was also measured in the serum using a high sensitivity ELISA kit. Physical activity measures and BMI was compared to assess the aerobic capacity, flexibility and effect of body weight on cytokine levels, with exercise.;There was a reduction seen in both the FLEX (strength and flexibility) and CARDIO (cardiovascular exercise) groups over ten months. There was a reduction in the IL-6 level in the CARDIO group, while there was an increase in the FLEX group. There were no changes in the TNF-alpha levels in either of the groups. No change in the serum cytokine levels in either group, a trend was seen in the CARDIO group. These results suggest that cardiovascular exercise may have a positive role in reducing the inflammatory effects of aging in an elderly population.
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
George, Joji, "Effect of cardiovascular exercise training compared to strength flexibility training on inflammatory mediators in an elderly population" (2008). Retrospective Theses and Dissertations. 15408.