Degree Type

Thesis

Date of Award

2008

Degree Name

Master of Science

Department

Kinesiology

First Advisor

Marian Kohut

Second Advisor

Warren Franke

Third Advisor

Joan Cunnick

Abstract

This longitudinal study was the first study to assess the effect of two different kinds of exercise on levels of proinflammatory cytokines in PBMC and serum. IL-1beta, TNF-alpha and IL-6 levels were measured using regular ELISA assay in PBMC; IL-6 was also measured in the serum using a high sensitivity ELISA kit. Physical activity measures and BMI was compared to assess the aerobic capacity, flexibility and effect of body weight on cytokine levels, with exercise.;There was a reduction seen in both the FLEX (strength and flexibility) and CARDIO (cardiovascular exercise) groups over ten months. There was a reduction in the IL-6 level in the CARDIO group, while there was an increase in the FLEX group. There were no changes in the TNF-alpha levels in either of the groups. No change in the serum cytokine levels in either group, a trend was seen in the CARDIO group. These results suggest that cardiovascular exercise may have a positive role in reducing the inflammatory effects of aging in an elderly population.

DOI

https://doi.org/10.31274/rtd-180813-16635

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Joji George

Language

en

Proquest ID

AAI1455127

OCLC Number

236992360

ISBN

9780549572091

File Format

application/pdf

File Size

845 pages

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