Degree Type
Dissertation
Date of Award
2005
Degree Name
Doctor of Philosophy
Department
Veterinary Microbiology and Preventive Medicine
First Advisor
Douglas E. Jones
Abstract
Leishmania major (L. major) is the most well-studied Leishmania species. Many classical studies on L. major have lead to the paradigm of Th1/Th2 dichotomy which has been a dogma in infectious disease research (137). Leishmania amazonensis (L. amazonensis), a New World species of Leishmania, cause a chronic diseases in many inbred mice with features distinct from L. major infection (105). A comparison in T cell response in these two infections has revealed defects in T cell response (105). However, a detailed study of dendrictic cell (DC) response during L. amazonensis infection has not been reported. Since DCs are the most potent antigen-presenting-cells (APC), a through understanding of DC defects will greatly facilitate our understanding of factors contributing to chronicity of L. amazonensis infection.;This dissertation focuses on the impairment of DC functions during L. amazonensis infection. Chapter 1 is a general introduction which includes the organization of dissertation and a regulates ERK activation which inhibit DC functions such as CD40 and IL-12 expression. NO is found to inhibit Th1 response in both L. amazonensis and L. major infections.
DOI
https://doi.org/10.31274/rtd-180813-12252
Publisher
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu
Copyright Owner
Fei Jie
Copyright Date
2005
Language
en
Proquest ID
AAI3184625
File Format
application/pdf
File Size
135 pages
Recommended Citation
Jie, Fei, "Impairment of dendritic cell functions during in vitro Leishmania amazonensis infection " (2005). Retrospective Theses and Dissertations. 1567.
https://lib.dr.iastate.edu/rtd/1567
Included in
Allergy and Immunology Commons, Immunology and Infectious Disease Commons, Medical Immunology Commons
