Degree Type

Dissertation

Date of Award

2005

Degree Name

Doctor of Philosophy

Department

Veterinary Microbiology and Preventive Medicine

First Advisor

Douglas E. Jones

Abstract

Leishmania major (L. major) is the most well-studied Leishmania species. Many classical studies on L. major have lead to the paradigm of Th1/Th2 dichotomy which has been a dogma in infectious disease research (137). Leishmania amazonensis (L. amazonensis), a New World species of Leishmania, cause a chronic diseases in many inbred mice with features distinct from L. major infection (105). A comparison in T cell response in these two infections has revealed defects in T cell response (105). However, a detailed study of dendrictic cell (DC) response during L. amazonensis infection has not been reported. Since DCs are the most potent antigen-presenting-cells (APC), a through understanding of DC defects will greatly facilitate our understanding of factors contributing to chronicity of L. amazonensis infection.;This dissertation focuses on the impairment of DC functions during L. amazonensis infection. Chapter 1 is a general introduction which includes the organization of dissertation and a regulates ERK activation which inhibit DC functions such as CD40 and IL-12 expression. NO is found to inhibit Th1 response in both L. amazonensis and L. major infections.

DOI

https://doi.org/10.31274/rtd-180813-12252

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu

Copyright Owner

Fei Jie

Language

en

Proquest ID

AAI3184625

File Format

application/pdf

File Size

135 pages

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